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Experimental collaborations in the UK Centre for Mammalian Synthetic Biology

We have developed a programme of social scientific research on responsible research and innovation
in the UK’s Centre for Mammalian Synthetic Biology. Our work has four main strands.

New approaches to RRI informed by art and design

Jane and Rob with Ionat Zurr, Oron Catts and Tarsh Bates from SymbioticA at the University of Western Australia, Erika Szymanski at Colorado State University, and the Rosser and Cachat laboratories at the CMSB have collaborated on the ‘Crossing Kingdoms’ project. This project attempts to fuse mammalian and yeast cells to explore the social, cultural and scientific implications of the hybrids produced. It has created interdisciplinary collaborations that make contributions to artistic, social scientific and natural scientific research agendas simultaneously.

Funding cultures and public science

As the development of synthetic biology shows, research funders are fundamental to the implementation of RRI and shaping the trajectory of the field more broadly. While the power of research funders is widely acknowledged, there have been few in-depth studies of their day-to-day decision making and even fewer opportunities to inform this decision making with social scientific research. Rob has been leading work with an international network of bioscience funding agencies (ERACoBioTech, which includes the BBSRC) to help them think about designing funding programmes that are themselves shaped by RRI.

Open research cultures in synthetic biology

Ros Attenborough has led this strand of research, which aims to unearth and discuss varied experiences of openness in research cultures in synthetic biology. Our first ‘Talking Freely‘ workshop explored the relationships between ideals of openness and the realities of everyday academic life. Ros has been awarded an ESRC postdoctoral fellowship, Open and healthy research cultures: bringing insights into policy and practice, to continue this research during 2021 and 2022.

Concepts of the human in mammalian synthetic biology

What roles do ideas of ‘the human’ play in mammalian synthetic biology? How do claims about human relevance shape synthetic biology practices? And how do human materials such as cell lines figure in the work of researchers in the lab? In her PhD, Sophie Stone works closely with mammalian synthetic biology laboratories to examine these questions and more.

Publications

Smith, R (2021) Crossing kingdoms, disciplines and continents: What can art, STS and synthetic biology do together? SynthSys Blog.

Szymanski, E, Bates, N, Cachat, E, Calvert, J, Catts, O, Nelson, LJ, Rosser, SJ, Smith, RDJ, Zurr, I (2020) ‘Crossing kingdoms: How can art open up new ways of thinking about science?’ Frontiers in Bioengineering & Biotechnology doi: 10.3389/fbioe.2020.00715

Szymanski, E.A., Smith, R.D.J. & Calvert, J. (2021) Responsible research and innovation meets multispecies studies: why RRI needs to be a more-than-human exercise. Journal of Responsible Innovation, 1-6.

Smith, R, Scott, D, Kamwendo, Z & Calvert, J (2019) An Agenda for Responsible Research and Innovation in ERA CoBioTech. Swindon, UK: Biotechnology and Biological Sciences Research Council.

Smith, R (2020) Responsible research and innovation as social learning: Insights from BBSRC and the ERA CoBioTech programme. Edinburgh Hub for Responsible Innovation Blog.

Smith, R.D.J., Hartley, S., Middleton, P., Jewitt, T. (2021) Knowing when to talk? Plant genome editing as a site for pre-engagement institutional reflexivity. Public Understanding of Science, 30, 740-758.

Smith, R.D.J. Kamwendo, Z.T., Berndt, A., Parkin, J (2021) Taking knowledge production seriously in responsible research and innovation. Journal of Responsible Innovation.

People

Jane Calvert

Jane Calvert

University of Edinburgh

Robert Smith

Robert Smith

University of Edinburgh

Ros Attenborough

Ros Attenborough

University of Edinburgh

Sophie Stone

Sophie Stone

University of Edinburgh